CYCLOPROPAMITOSENES - NOVEL BIOREDUCTIVE ANTICANCER AGENTS - MECHANISM OF ACTION AND ENZYMATIC REDUCTION

Authors
MOODY CJ OSULLIVAN N STRATFORD IJ STEPHENS MA WORKMAN P BAILEY SM LEWIS A
Citation
Cj. Moody et al., CYCLOPROPAMITOSENES - NOVEL BIOREDUCTIVE ANTICANCER AGENTS - MECHANISM OF ACTION AND ENZYMATIC REDUCTION, Anti-cancer drugs, 5(3), 1994, pp. 367-372
Citations number
39
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
Anti-cancer drugs → ACNP
ISSN journal
09594973
Volume
5
Issue
3
Year of publication
1994
Pages
367 - 372
Database
ISI
SICI code
0959-4973(1994)5:3<367:C-NBAA>2.0.ZU;2-P
Abstract
The mechanism of action of cyclopropamitosenes, novel bioreductive ant icancer agents, has been investigated using a unique combination of ch emical and blochemical techniques. The compounds 4 function as reducti vely activated alkylating agents under chemical reducing conditions, a nd the blochemical experiments establish that the methoxy- and aziridi nyl-derivatives 4a and 4b behave differently upon bioreduction.