POLYMORPHIC ARYLAMINE N-ACETYLTRANSFERASE ENCODING GENE (NAT2) FROM HOMOZYGOUS RAPID AND SLOW ACETYLATOR CONGENIC SYRIAN-HAMSTERS

Authors
FERGUSON RJ DOLL MA BAUMSTARK BR HEIN DW
Citation
Rj. Ferguson et al., POLYMORPHIC ARYLAMINE N-ACETYLTRANSFERASE ENCODING GENE (NAT2) FROM HOMOZYGOUS RAPID AND SLOW ACETYLATOR CONGENIC SYRIAN-HAMSTERS, Gene, 140(2), 1994, pp. 247-249
Citations number
12
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
140
Issue
2
Year of publication
1994
Pages
247 - 249
Database
ISI
SICI code
0378-1119(1994)140:2<247:PANEG(>2.0.ZU;2-D
Abstract
The nucleotide (nt) and deduced amino acid (aa) sequences were determi ned for polymorphic arylamine N-acetyl-transferase (NAT2) and its gene , NAT2, from homozygous rapid and slow acetylator congenic Syrian hams ters. The slow acetylator (NAT2s) allele contained three point mutatio ns which differed from the rapid acetylator allele (NAT2r); two mutati ons were silent, and the third mutation resulted in a premature stop c odon. The NAT2s allele contained a truncated open reading frame of 726 nt encoding a 242-aa protein, which is 48-aa shorter than NAT2.