THE MURINE GLUTAMINE FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE-ENCODING CDNA SEQUENCE

Authors
SAYESKI PP PATERSON AJ KUDLOW JE
Citation
Pp. Sayeski et al., THE MURINE GLUTAMINE FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE-ENCODING CDNA SEQUENCE, Gene, 140(2), 1994, pp. 289-290
Citations number
4
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
140
Issue
2
Year of publication
1994
Pages
289 - 290
Database
ISI
SICI code
0378-1119(1994)140:2<289:TMGFAC>2.0.ZU;2-4
Abstract
Glutamine:fructose-6-phosphate amidotransferase (GFAT) is the rate-lim iting enzyme in hexosamine synthesis and has been implicated in the co ntrol of growth factor gene expression. We cloned a mouse cDNA which i s 91% homologous to the human sequence. The deduced amino-acid sequenc e shows 98.6% identity to human GFAT. The cDNA is derived from a 7-kb mRNA in the mouse, while there are multiple-sized human mRNAs.