A retrospective study was designed to examine whether the presence of
a hydrosalpinx influenced pregnancy outcome following in-vitro fertili
zation (IVF) treatment in stimulated cycles. A total of 254 women with
tubal lesions were included. Patients with one or two hydrosalpinges
were compared with patients having other tubal lesions and pregnancy o
utcome was analysed. Both pregnancy and delivery rates were significan
tly higher in the patient group without a hydrosalpinx. The results af
ter frozen embryo transfer showed the same tendency. These findings st
rongly indicate that a permanent hydrosalpinx has a negative influence
on implantation, as well as on pregnancy, and suggest that a more act
ive approach against large hydrosalpinges should be undertaken before
IVF treatment, in order to improve the pregnancy rates.