STABILITY BEHAVIOR OF MOLSIDOMINE-CONTAINING PELLET FORMULATIONS

Molsidomine in mixtures with different inactive ingredients has been s ubjected to a stability test. The fingerprint chromatogram obtained by HPLC with diode-array detection of mixtures of molsidomine with povid one 25 revealed decomposition products; the detection wavelength of 21 0 nm resulted in easy detection of the degradation products. Molsidomi ne-containing pellets were manufactured according to a compact procedu re and by applying the active ingredient to placebo pellets. Compared with the nonpareil pellet formulations, compact pellets have a conside rably higher water content and undergo decomposition of the active ing redient after storage for 50 months under different conditions. It is assumed that the decomposition of molsidomine is accelerated by the pe roxide found in povidone.