ABSORPTION OF CIPROFLOXACIN AND NORFLOXACIN WHEN ADMINISTERED AS NIOSOME-ENCAPSULATED INCLUSION COMPLEXES

An attempt has been made to design suitable niosome-encapsulated drug delivery system for ciprofloxacin and norfloxacin. Encapsulation of ci profloxacin and norfloxacin in niosomes was investigated and the nasal and intestinal absorption of the products studied. More than 80% of t he drugs were successfully encapsulated to give products with sustaine d release characteristics. Encapsulation in niosomes also improved the stability of the antibacterial compounds. Although the systemic avail ability of these niosome-encapsulated antibacterial compounds was not increased after nasal administration, intestinal absorption was signif icantly higher in comparison with that of plain inclusion complexes.