PREDICTIONS OF WHICH DIASTEREOISOMERIC SALT PRECIPITATES DURING AN OPTICAL RESOLUTION VIA DIASTEREOISOMERIC SALT FORMATION

The DSC data of sixteen conglomerate forming diastereoisomeric salt pa irs were analysed. It was demonstrated that during optical resolution via fractional crystallization of diastereoisomeric salt pain always t hat diastereoisomeric salt precipitates which has the higher melting p oint. When one of the salts is amorphous that remains in the mother li quor. If one of the diastereoisomeric salt crystallizes with solvate t hat will precipitate during optical resolutions.