LIPASE-CATALYZED AMINOLYSIS AND AMMONOLYSIS OF BETA-KETOESTERS - SYNTHESIS OF OPTICALLY-ACTIVE BETA-KETOAMIDES

Authors
GARCIA MJ REBOLLEDO F GOTOR V
Citation
Mj. Garcia et al., LIPASE-CATALYZED AMINOLYSIS AND AMMONOLYSIS OF BETA-KETOESTERS - SYNTHESIS OF OPTICALLY-ACTIVE BETA-KETOAMIDES, Tetrahedron, 50(23), 1994, pp. 6935-6940
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
23
Year of publication
1994
Pages
6935 - 6940
Database
ISI
SICI code
0040-4020(1994)50:23<6935:LAAAOB>2.0.ZU;2-#
Abstract
Aminolysis and ammonolysis reactions of beta-ketoesters catalyzed by C andida antarctica lipase ar e very efficient methods for the preparati on of beta-ketoamides. When racemic amines are used in these precesses , the corresponding optically active beta-ketoamides are obtained with moderate-high enantiomeric excesses.