Mj. Garcia et al., LIPASE-CATALYZED AMINOLYSIS AND AMMONOLYSIS OF BETA-KETOESTERS - SYNTHESIS OF OPTICALLY-ACTIVE BETA-KETOAMIDES, Tetrahedron, 50(23), 1994, pp. 6935-6940
Aminolysis and ammonolysis reactions of beta-ketoesters catalyzed by C
andida antarctica lipase ar e very efficient methods for the preparati
on of beta-ketoamides. When racemic amines are used in these precesses
, the corresponding optically active beta-ketoamides are obtained with
moderate-high enantiomeric excesses.