COMPLETE REMISSION FOLLOWING DONOR PBSC AFTER LOW-DOSE CYTARABINE CHEMOTHERAPY FOR EARLY RELAPSE OF ACUTE MYELOGENOUS LEUKEMIA AFTER ALLOGENEIC STEM-CELL TRANSPLANTATION

A 55-year-old woman with chemotherapy-resistant acute myeloblastic leu kemia (AML M2) relapsed 3 months after allogeneic PBSC transplant. The patient was treated with two cycles of low-dose cytarabine chemothera py followed by G-CSF mobilized donor PBSC after cessation of all immun osuppressive treatment, Hematological and cytogenetic complete remissi on was observed after the first cycle. The patient had been previously treated for AGVHD after allogeneic PBSC transplantation and experienc ed a second AGVHD after the second cycles of cytoreductive treatment a nd donor PBSC infusion, Hematological recovery after donor PBSC infusi on was faster than recovery after previous chemotherapy or high-dose c hemotherapy, During treatment no febrile neutropenia was observed. Thi s case shows that donor PBSC infusion cannot only provide prolonged co mplete hematological and cytogenetic remission but also seems to suppo rt accelerated hematopoietic recovery for some patients relapsing afte r allogeneic BMT.