ALLOGENEIC BONE-MARROW TRANSPLANT FOR CHRONIC MYELOGENOUS LEUKEMIA INA PATIENT WITH MULTIPLE-SCLEROSIS

Multiple sclerosis (MS) is a demyelinating disease of the central nerv ous system in which immune mechanisms appear to be an important compon ent of the pathophysiology. Although the clinical manifestations are v ariable, a subset of patients develops a progressive clinical course a ssociated with marked neurologic impairment and significant morbidity, BMT has been proposed as a treatment for such patients based on precl inical data as well as clinical observations in other autoimmune disea ses. We report clinical and MRI findings in an MS patient, later diagn osed with CML, and treated with an allogeneic BMT.