EFFECT OF PLATELET-ACTIVATING-FACTOR (PAF) ON THE FORMATION OF BLOOD-VESSELS IN SUBCUTANEOUS IMPLANTS IN MICE

Authors
ANDRADE SP VIEIRA LBGB BAKHLE YS PIPER PJ
Citation
Sp. Andrade et al., EFFECT OF PLATELET-ACTIVATING-FACTOR (PAF) ON THE FORMATION OF BLOOD-VESSELS IN SUBCUTANEOUS IMPLANTS IN MICE, Journal of lipid mediators and cell signalling, 9(2), 1994, pp. 117-121
Citations number
10
Categorie Soggetti
Biology,"Cytology & Histology
Journal title
Journal of lipid mediators and cell signalling → ACNP
ISSN journal
09297855
Volume
9
Issue
2
Year of publication
1994
Pages
117 - 121
Database
ISI
SICI code
0929-7855(1994)9:2<117:EOP(OT>2.0.ZU;2-4
Abstract
Angiogenesis accompanies inflammatory processes and many other patholo gical conditions. We have studied the effect of platelet-activating fa ctor (PAF) a well-known inflammatory mediator, as a promoter of angiog enesis in the sponge implant model in mice. Development of blood vesse ls and blood flow were monitored by use of a Xe-133 washout technique. The results showed PAF to have angiogenic activity, which was inhibit ed by WEB 2086, and the PAF-induced vasculature to have normal pharmac ological reactivity.