One hundred and twenty cases of stroke occurring in Saudi Arabian subj
ects aged 15 to 45 years are reviewed. These constituted 12.7% of a gr
oup of 946 stroke patients. Males outnumbered females (76/44). The fre
quency of intracranial hemorrhage, including subarachnoid hemorrhage,
was slightly lower than cerebral infarction (41.5 vs 58.5%). The cause
s of large cerebral infarction were as follows: atherosclerosis 17 (28
%), cardiac embolism 12 (19.5%), uncommon and uncertain causes 21 (34.
5%). Some unusual causes were encountered such as dissecting arterial
aneurysm due to popular healing manoeuvres or to traditional dance, re
trograde embolism from a thoracic outlet syndrome or embolism from a f
ibroelastoma of the mitral valve chorda. Lacunar cerebral infarction w
as diagnosed in nine cases. Hypertension (25.5%) and arteriovenous mal
formations (20.5%) were the main causes of cerebral hemorrhage; all su
barachnoid hemorrhages except one were due to berry aneurysms. The cau
se was undetermined in 16% of cerebral infarction and 26% of intracran
ial hemorrhage. The high frequency of stroke in young Saudi Arabian ad
ults is probably a reflection of the demographic structure of the pred
ominantly young Saudi society. The observed causes were relatively sim
ilar to those in industrial societies. Contrary to other developing co
untries infectious disease no longer seems to be an important cause of
stroke. Drug abuse, which is becoming an important cause in Western s
ocieties, was encountered in only two of our cases.