A DOUBLE-BLIND-STUDY OF NEUROTROPIN IN PATIENTS WITH ACUTE ISCHEMIC STROKE

Neurotropin was found to reduce brain oedema in an experimental model of brain infarction in the guinea-pig. A randomized double-blind contr olled trial with Neurotropin, was performed in 220 patients admitted w ithin 24 h after an acute ischemic stroke. 35 of the neurotropin and 4 1 of the placebo-randomized patients had to be excluded. 10 included p atients in the neurotropin and 13 in the placebo-treated group died wi thin the study period of 15 days. A better clinical outcome was observ ed in the 65 included surviving neurotropin compared with the 56 place bo-treated patients. The size of the infarct and of the oedema zones w as significantly more decreased on CTscans from Day 11 compared with D ay 3 after stroke in the neurotropin than in the placebo treated group . Neurotropin is helpful in treating brain oedema, related to acute is chemic stroke.