NEUROENDOCRINE PHENOTYPE DIFFERENTIATION IN A HAMSTER LUNG EPITHELIAL-CELL LINE UNDER LOW-OXYGEN PRESSURE OR AFTER TRANSFORMATION BY DIETHYLNITROSAMINE

Authors
EMURA M OCHIAI A GOBERTBOHLEN A PANNING B DUNGWORTH DL
Citation
M. Emura et al., NEUROENDOCRINE PHENOTYPE DIFFERENTIATION IN A HAMSTER LUNG EPITHELIAL-CELL LINE UNDER LOW-OXYGEN PRESSURE OR AFTER TRANSFORMATION BY DIETHYLNITROSAMINE, Toxicology letters, 72(1-3), 1994, pp. 59-64
Citations number
17
Categorie Soggetti
Toxicology
Journal title
Toxicology letters → ACNP
ISSN journal
03784274
Volume
72
Issue
1-3
Year of publication
1994
Pages
59 - 64
Database
ISI
SICI code
0378-4274(1994)72:1-3<59:NPDIAH>2.0.ZU;2-I
Abstract
Oxygen pressure as low as 5% in the gas phase or 87 mmHg in the liquid phase induced various neuroendocrine cell (NEC) phenotypes in more th an 80% of cells of a cloned fetal Syrian hamster lung epithelial cell line (M3E3/C3). Further, cells from a number of colonies transformed i n an anchorage-independent manner by diethylnitrosamine (DEN) demonstr ated a NEC phenotype. Since the cell line used is of a pluripotent ste m cell type, both hypoxia and DEN appear to possess a potency for NEC phenotype induction.