MORPHOLOGIC EFFECTS OF A SULFUR(IV) AEROSOL ON THE NASAL CAVITY OF BEAGLE DOGS

Authors
TAKENAKA S FURST G HEILMANN P HEINI A HEINZMANN U KARG E MURRAY AB RUPRECHT L HEYDER J
Citation
S. Takenaka et al., MORPHOLOGIC EFFECTS OF A SULFUR(IV) AEROSOL ON THE NASAL CAVITY OF BEAGLE DOGS, Toxicology letters, 72(1-3), 1994, pp. 145-150
Citations number
16
Categorie Soggetti
Toxicology
Journal title
Toxicology letters → ACNP
ISSN journal
03784274
Volume
72
Issue
1-3
Year of publication
1994
Pages
145 - 150
Database
ISI
SICI code
0378-4274(1994)72:1-3<145:MEOASA>2.0.ZU;2-F
Abstract
Morphologic changes were observed in nasal cavities of beagle dogs aft er long-term exposure to a respirable sulfur(IV) aerosol at a concentr ation equivalent to a sulfur dioxide (SO2) concentration of 0.6 mg/m(3 ). The changes were characterized by a thickened epithelial layer resu lting from epithelial proliferation, by a loss of secretory material, and by moderate mononuclear cell infiltration.