UNBALANCED 17 TRANSLOCATION IN MYELODYSPLASTIC SYNDROME FOLLOWING TREATMENT OF ACUTE MYELOBLASTIC-LEUKEMIA WITH AN 8,22 TRANSLOCATION

The chromosome der(1;7)(q10;p10) consists of the short arm of chromoso me 7 and the long arm of chromosome 1, and is a common abnormality in treatment-related leukemia and myelodysplastic syndrome. Here we descr ibe a 39-year-old Japanese man with acute myeloblastic leukemia (FAB-M 2) exhibiting t(8;21)(q22;q22). He entered complete remission after in duction therapy, and intensification therapy including alkylating agen ts was subsequently continued for 3 years. The patient then developed pancytopenia; bone marrow aspiration revealed myelodysplastic syndrome exhibiting the der (1;7) chromosome. To our knowledge, this is the fi rst reported case of such on abnormality in myelodysplastic syndrome s econdary to acute myeloblastic leukemia with the 8;21 translocation.