A CASE OF ACUTE MONOCYTIC LEUKEMIA WITH T(1117) INVOLVING A REARRANGEMENT OF MLL-1 AND A REGION PROXIMAL TO THE RARA GENE

Authors
REEVES BR KEMPSKI H JANI K BORROW J HOWE K SOLOMON E KEARNEY L COTTER F
Citation
Br. Reeves et al., A CASE OF ACUTE MONOCYTIC LEUKEMIA WITH T(1117) INVOLVING A REARRANGEMENT OF MLL-1 AND A REGION PROXIMAL TO THE RARA GENE, Cancer genetics and cytogenetics, 74(1), 1994, pp. 50-53
Citations number
21
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
74
Issue
1
Year of publication
1994
Pages
50 - 53
Database
ISI
SICI code
0165-4608(1994)74:1<50:ACOAML>2.0.ZU;2-O
Abstract
A case of acute monocytic leukemia with t(11;17)(q23;q11-21) arising i n a 4-month-old boy is described. The breakpoint on chromosome 11 coul d be mapped to on 8-kb BamHI fragment within the MLL-1 gene, as seen i n the majority of infant leukemias. In situ hybridization with cosmid probes allowed us to map the breakpoint on 17q proximal to the RARA ge ne, while Southern and Northern analyses showed that the gene was not disrupted by the translocation.