INFLUENCE OF LITHIUM-SALTS ON CHICK PINEAL-GLAND MELATONIN SECRETION

Citation
Mi. Pablos et al., INFLUENCE OF LITHIUM-SALTS ON CHICK PINEAL-GLAND MELATONIN SECRETION, Neuroscience letters, 174(1), 1994, pp. 55-57
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
03043940
Volume
174
Issue
1
Year of publication
1994
Pages
55 - 57
Database
ISI
SICI code
0304-3940(1994)174:1<55:IOLOCP>2.0.ZU;2-G
Abstract
Pineal melatonin secretion exhibits a rhythm which is identified as a circadian cycle with a period of between 20 and 28 h in most animals. The melatonin rhythm has an acrophase of about -30 degrees. The aim of this study was determine the effect of lithium on the melatonin rhyth m since lithium is usually used as a therapeutic agent in manic-depres sive desease. Lithium induced a delay of the melatonin acrophase which reached a value of about -45 degrees; lithium also produced another p eak which had an acrophase at about +60 degrees. We speculate that lit hium influences either inositol phosphate turnover or it merely change s the profile of the melatonin rhythm.