DOUBLE-BLIND TRIAL OF DEXAMETHASONE VERSUS METHYLPREDNISOLONE IN MULTIPLE-SCLEROSIS ACUTE RELAPSES

Authors
LAMANTIA L EOLI M MILANESE C SALMAGGI A DUFOUR A TORRI V
Citation
L. Lamantia et al., DOUBLE-BLIND TRIAL OF DEXAMETHASONE VERSUS METHYLPREDNISOLONE IN MULTIPLE-SCLEROSIS ACUTE RELAPSES, European neurology, 34(4), 1994, pp. 199-203
Citations number
22
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
European neurology → ACNP
ISSN journal
00143022
Volume
34
Issue
4
Year of publication
1994
Pages
199 - 203
Database
ISI
SICI code
0014-3022(1994)34:4<199:DTODVM>2.0.ZU;2-5
Abstract
The efficacy of dexamethasone (DX) and methylprednisolone (MP) at high (HD) and low (LD) dose in acute multiple sclerosis (MS) relapses was evaluated by a double-blind trial in 31 patients followed for 1 year. DX and HDMP were similarly efficacious in promoting recovery, while LD MP was ineffective in the short-term outcome and was followed by an ea rly clinical reactivation. The different outcomes seem to be related t o different immunomodulating effects, mainly on cerebrospinal fluid (C SF) IgG synthesis and on peripheral blood and CSF CD4(+) lymphocyte su bsets.