GM HAPLOTYPES IN CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY IN JAPANESE PATIENTS

We studied the serum Gm allotype of 58 patients with chronic inflammat ory demyelinating polyradiculoneuropathy (CIDP) and 236 nonrelated nor mal controls in Japan. The incidences of the Gm phenotype and haplotyp e in the patients were not significantly different from those in the n ormal controls. When CIDP was classified into two subgroups in terms o f clinical course, the chronic relapsing (CR) and chronic nonrelapsing type (CNR), the distribution of all Gm haplotypes was significantly d ifferent between CR and CNR (total chi(2) = 8.319; corrected p < 0.05) . Our findings suggest that the clinical course of CIDP may be associa ted with the Gm haplotype.