STEREOSELECTIVE PHOSPHONYLATION OF ALDEHYDES VIA CHIRAL PHOSPHORDIAMIDITES - A POTENTIALLY VERSATILE ASYMMETRIC ROUTE TO ORGANOPHOSPHORUS BIOMOLECULES

Authors
SUM V KEE TP THORNTONPETT M
Citation
V. Sum et al., STEREOSELECTIVE PHOSPHONYLATION OF ALDEHYDES VIA CHIRAL PHOSPHORDIAMIDITES - A POTENTIALLY VERSATILE ASYMMETRIC ROUTE TO ORGANOPHOSPHORUS BIOMOLECULES, Journal of the Chemical Society, Chemical Communications, (6), 1994, pp. 743-744
Citations number
27
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
6
Year of publication
1994
Pages
743 - 744
Database
ISI
SICI code
0022-4936(1994):6<743:SPOAVC>2.0.ZU;2-G
Abstract
The novel, chiral phosphordiamidite, {N,O-(1R,2S)-MeNCHMeCHPhO}PN(SiMe 3)2 containing deprotonated ephidrine has been shown to phosphonylate aldehydes readily to afford alpha-functionalised phosphonate esters wi th diasteroselectivities up to ca. 96%.