SYNTHESIS, STRUCTURE AND MECHANISM IN IMMUNOPHILIN RESEARCH

The ability to synthesize new molecular structures can greatly augment investigations of cellular systems. Synthetic chemistry coupled with structure determination is an especially powerful combination. These t echniques have played a vital role in both the discovery and character ization of a family of intracellular receptors known as immunophilins. This review will attempt to highlight the synthetic and structural st udies of immunophilin receptors that have been carried out in the Harv ard and Cornell laboratories during the past several years.