ASYMMETRIC INDUCTION IN RADICAL CYCLIZATION LEADING TO BETA-LACTAMS -FORMAL SYNTHESIS OF (-PS-5())

Authors
ISHIBASHI H KAMEOKA C SATO T IKEDA M
Citation
H. Ishibashi et al., ASYMMETRIC INDUCTION IN RADICAL CYCLIZATION LEADING TO BETA-LACTAMS -FORMAL SYNTHESIS OF (-PS-5()), Synlett, (6), 1994, pp. 445-446
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
6
Year of publication
1994
Pages
445 - 446
Database
ISI
SICI code
0936-5214(1994):6<445:AIIRCL>2.0.ZU;2-C
Abstract
Tributyltin hydride-mediated radical cyclization of 2,2-bis(phenylthio )ethenyl]-alpha-bromoalkanamides bearing (S)-1-phenylethyl group on th e nitrogen atom gave (4S)-4-bis(phenylthio)-methyl-2-azetidinones as m ajor products. The method was applied to the synthesis of a chiral pre cursor of carbapenem antibiotic (+)-PS-5.