ZIRCONOCENE-MEDIATED SYNTHESIS OF 3,4-DISUBSTITUTED PIPERIDINES AND REDUCED ISOQUINOLINES

Authors
KEMP MI WHITBY RJ COOTE SJ
Citation
Mi. Kemp et al., ZIRCONOCENE-MEDIATED SYNTHESIS OF 3,4-DISUBSTITUTED PIPERIDINES AND REDUCED ISOQUINOLINES, Synlett, (6), 1994, pp. 451-453
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
6
Year of publication
1994
Pages
451 - 453
Database
ISI
SICI code
0936-5214(1994):6<451:ZSO3PA>2.0.ZU;2-7
Abstract
4-Aza-1,7-octa-dienes, -enynes, -ynenes and -diynes are converted to 3 -aza-8-zirconabicyclo[4.3.0]non-anes, -6-enes, 9-enes or 6,9-dienes wh en treated with 'ZrCP2' (where Cp = eta5-C5H5). Protonolysis, iodinoly sis, or carbonylation of these complexes affords 3,4-disubstituted pip eridines. 1,3-Dienes formed from the coupling / protonolysis of 4-aza- 1,7-octadiynes react with activated dienophiles to yield reduced isoqu inolines.