Primary gastric lymphoma are nowadays considered as a distinct lymphom
a entity. Their classification is based on the concept of MALT (Mucosa
-associated lymphoid tissue). Within the gastrointestinal tract, the s
tomach is most frequently involved. In the pathogenesis of gastric lym
phoma, Helicobacter pylori-associated gastritis plays all important, c
onditioning role. Usually, the diagnosis of gastric lymphoma can be es
tablished on the basis of endoscopic biopsies. Endoscopic ultrasound s
eems highly useful for differentiating the depth of lymphoma infiltrat
ion and for evaluating the perigastric lymph nodes. Options in the the
rapy of gastric lymphoma are based on their histological grade and sta
ge of the disease. They include surgical resection and/or radiotherapy
tor local tumor control as well as chemotherapy in the case of dissem
inated disease or high malignancy. Currently, special interest focuses
on the effect of Helicobacter pylori eradication.