We report on three family members suffering from both autosomal domina
nt Hailey-Hailey disease and bipolar affective disorder. As molecular
biology techniques have made the localization of genes causing simple
Mendelian traits possible as a routine task, the gene for Hailey-Haile
y disease will presumably be localized in the foreseeable future. The
Hailey-Hailey gene and its chromosomal surrounding will then be a regi
on of interest for linkage studies in bipolar affective disorder.