Time-domain ultrasonography is an alternative to Doppler analysis of b
lood flow direction and velocity. The technique uses timing informatio
n between successive echo pulses to measure flow velocities directly t
hrough a color display map. Volume flow quantification also can be ach
ieved by combining time-domain methods with M-mode ultrasonography. Th
is report describes our preliminary experiences with fetal vascular im
aging by time-domain ultrasonography, compares Doppler peak velocity c
orrelation to time-domain sonography, and examines the in vitro accura
cy of time-domain sonography combined with M-mode volume flow measurem
ents. Excellent agreement was found between peak Doppler velocity meas
urements and time-domain ultrasonography for a variety of maternal and
fetal vessels (N = 29). Close volume-flow correlation was observed be
tween a flow pump and time-domain ultrasonography under constant and p
ulsatile conditions. Time-domain ultrasonography appears to be a usefu
l alternative to Doppler techniques for imaging small fetal vessels an
d also may provide the basis for accurate volume flow measurements dur
ing pregnancy.