MELANOTROPES OF THE LIZARD, ANOLIS-CAROLINENSIS, LACK N-ACETYLATING MECHANISMS FOR BOTH ALPHA-MELANOCYTE-STIMULATING HORMONE AND BETA-ENDORPHIN

Authors
DORES RM WASINGER H VAUDRY D STEVESON T LANCHA A
Citation
Rm. Dores et al., MELANOTROPES OF THE LIZARD, ANOLIS-CAROLINENSIS, LACK N-ACETYLATING MECHANISMS FOR BOTH ALPHA-MELANOCYTE-STIMULATING HORMONE AND BETA-ENDORPHIN, Neuroendocrinology, 59(6), 1994, pp. 603-609
Citations number
34
Categorie Soggetti
Neurosciences,"Endocrynology & Metabolism
Journal title
Neuroendocrinology → ACNP
ISSN journal
00283835
Volume
59
Issue
6
Year of publication
1994
Pages
603 - 609
Database
ISI
SICI code
0028-3835(1994)59:6<603:MOTLAL>2.0.ZU;2-V
Abstract
In order to determine whether Anolis carolinensis intermediate pituita ry cells have the capacity to N-acetylate either ACTH(1-13)NH2 or beta -endorphin during secretion, individual intermediate pituitary explant s were incubated in DMEM/CO2 for 24 h at 28 degrees C. Although alpha- melanocyte-stimulating hormone (alpha-MSH)- and beta-endorphin-related products were spontaneously released into the medium, none of these f orms were N-acetylated. It appears that unlike most gnathostomes, A. c arolinensis has secondarily lost the POMC-specific N-acetylation mecha nisms. A ramification of this observation is that the alpha-MSH for A. carolinensis is ACTH (1-13)NH2.