SOME PHARMACEUTICAL PROPERTIES OF 2,3,6-PARTIALLY METHYLATED-BETA-CYCLODEXTRIN AND ITS SOLUBILIZING AND STABILIZING ABILITIES

The pharmaceutical properties of 2,3,6-partially methylated-beta-cyclo dextrin(PMCD) were investigated. The aqueous solubility bf PMCD was mu ch higher than that of the parent beta-CyD, and it exhibited endotherm ic dissolution in contrast to that of the conventional heptakis-(2,6-d i-O- methyl)-beta-cyclodextrin(DMCD). The acid-catalyzed hydrolysis ra te of PMCD was faster than those of the parent beta-CyD and DMCD. The hemolytic activity(human erythrocytes) of PMCD was similar to that of DMCD. PMCD was a more effective solubilizer for poorly water-soluble d rugs than the parent beta-CyD; however PMCD is not as effective as DMC D. The stabilizing effect of PMCD on chemically unstable drugs was hig her than that of the parent beta-CyD.