D. Ou et al., SOME PHARMACEUTICAL PROPERTIES OF 2,3,6-PARTIALLY METHYLATED-BETA-CYCLODEXTRIN AND ITS SOLUBILIZING AND STABILIZING ABILITIES, Drug development and industrial pharmacy, 20(12), 1994, pp. 2005-2016
The pharmaceutical properties of 2,3,6-partially methylated-beta-cyclo
dextrin(PMCD) were investigated. The aqueous solubility bf PMCD was mu
ch higher than that of the parent beta-CyD, and it exhibited endotherm
ic dissolution in contrast to that of the conventional heptakis-(2,6-d
i-O- methyl)-beta-cyclodextrin(DMCD). The acid-catalyzed hydrolysis ra
te of PMCD was faster than those of the parent beta-CyD and DMCD. The
hemolytic activity(human erythrocytes) of PMCD was similar to that of
DMCD. PMCD was a more effective solubilizer for poorly water-soluble d
rugs than the parent beta-CyD; however PMCD is not as effective as DMC
D. The stabilizing effect of PMCD on chemically unstable drugs was hig
her than that of the parent beta-CyD.