COEXISTENCE OF GLUCOCORTICOID RECEPTOR AND PHARMACOKINETIC ABNORMALITIES - FACTORS THAT CONTRIBUTE TO A POOR RESPONSE TO TREATMENT WITH GLUCOCORTICOIDS IN CHILDREN WITH ASTHMA

Authors
KAMADA AK SPAHN JD SURS W BROWN E LEUNG DYM SZEFLER SJ
Citation
Ak. Kamada et al., COEXISTENCE OF GLUCOCORTICOID RECEPTOR AND PHARMACOKINETIC ABNORMALITIES - FACTORS THAT CONTRIBUTE TO A POOR RESPONSE TO TREATMENT WITH GLUCOCORTICOIDS IN CHILDREN WITH ASTHMA, The Journal of pediatrics, 124(6), 1994, pp. 984-986
Citations number
9
Categorie Soggetti
Pediatrics
Journal title
The Journal of pediatrics → ACNP
ISSN journal
00223476
Volume
124
Issue
6
Year of publication
1994
Pages
984 - 986
Database
ISI
SICI code
0022-3476(1994)124:6<984:COGRAP>2.0.ZU;2-Q
Abstract
Rapid glucocorticoid clearance and abnormal glucocorticoid receptor bi nding have been described as factors that contribute to an inadequate response to treatment with glucocorticoids in patients with asthma. We report the coexistence of these abnormalities in children with severe asthma who respond poorly to systemic glucocorticoid therapy.