I. Elbagory et al., THE EFFECT OF GAMMA-RADIATION ON THE TABLETING PROPERTIES OF SOME PHARMACEUTICAL EXCIPIENTS, International journal of pharmaceutics, 105(3), 1994, pp. 255-258
Gamma radiation should provide an acceptable method for the sterilizat
ion of tableting excipients provided there are no deleterious effects
on tableting properties. Three direct compression excipients and maize
starch were exposed to gamma radiation at doses of 0, 5, 10 and 25 kG
y. Tablets were compressed on an instrumented rotary press. No measura
ble differences were found between the tableting properties of the irr
adiated and non-irradiated materials. The effectiveness of maize starc
h as a disintegrant was not affected by radiation.