LIPID MEDIATORS AND PROTEIN-KINASE-C ACTIVATION FOR THE INTRACELLULARSIGNALING NETWORK

Upon stimulation of a cell surface receptor, a membrane phospholipid d egradation cascade is often induced through the activation of several phospholipases, yielding various lipid metabolites such as diacylglyce rol, free fatty acids, lysophospholipids, and phosphatidic acid. Sever al isoforms of protein kinase C are each activated distinctly by vario us combinations of the lipid metabolites, presumably in different subc ellular compartments. The pivotal role of this enzyme family in the in tracellular signaling network is beginning to emerge.