SWEETS-SYNDROME - CLINICOPATHOLOGICAL STUDY OF 11 CASES

Background. The clinicopathologic manifestations of Sweet's syndrome a ssociated with malignancy have been rarely studied in a large series. Methods. We describe the clinical features of Sweet's syndrome in 11 p atients seen during the past 12 years. Histopathologic findings of the se patients are discussed. The clinicopathologic manifestations of 249 cases of Sweet's syndrome reported in the literature were reviewed. R esults. The clinicopathologic manifestations of Sweet's syndrome assoc iated with hematologic disorders (HSS) were more severe and characteri zed by bullous pyoderma with more pronounced epidermal changes and ulc eration, anemia, giant platelets and abnormal platelet counts. Approxi mately 40% of the Sweet's syndrome reported in the literature were ass ociated with hematologic malignancy, and the other 7% of patients had solid tumors. Conclusions. Sweet's syndrome can be classified into thr ee types: (1) association with hematologic disorders (HSS); (2) associ ation with solid tumors (sss); and (3) idiopathic or associated with v arious other disorders (ISS).