LAMINS AND LAMIN-ASSOCIATED PROTEINS

A variety of morphological and biochemical studies have established th at the nuclear lamins play an important role in nuclear structure and dynamics. Recent work reveals the existence of specialized lamin isoty pes and novel pathways of modulation of lamin import into the nucleus via phosphorylation by protein kinase C. Other studies also unveil a w ide spectrum of molecular interactions between the lamin proteins and integral membrane components of the nuclear envelope.