POSTANTIBIOTIC EFFECTS OF CEFDINIR ON ESCHERICHIA-COLI, KLEBSIELLA-PNEUMONIAE, STAPHYLOCOCCUS-AUREUS AND STREPTOCOCCUS-PYOGENES

The post-antibiotic effects (PAEs) of a new cephalosporin, cefdinir, w ere determined against a range of organisms using a viable counting te chnique. Cefdinir exerted considerable PAEs against Staphylococcus aur eus and Streptococcus pyogenes, but no overall post-antibiotic inhibit ion of growth was detected against Escherichia coli or Klebsiella pneu moniae. Exposure to cefdinir made the gram-negative organisms suscepti ble to the washing procedure used for drug removal, but this was follo wed by rapid recovery of viability in drug-free broth.