MYELIN BASIC-PROTEIN GENE POLYMORPHISM IS NOT ASSOCIATED WITH CHRONICPROGRESSIVE MULTIPLE-SCLEROSIS

In the present study a tetranucleotide (TGGA)n repeat polymorphism 5' to the myelin basic protein (MBP) gene was evaluated in a group of HLA -class II-typed, chronic progressive multiple sclerosis (MS) patients. This polymorphism has been reported by others to be associated with M S. Contrary to these reports we observed similar allele frequencies in patients and controls. Our results indicate that there is no associat ion between MS and a polymorphism 5' to the MBP gene.