INHIBITION OF P53-MEDIATED TRANSACTIVATION BY E6 OF TYPE-1, BUT NOT TYPE-5 TYPE-8, OR TYPE-47, HUMAN PAPILLOMAVIRUS OF CUTANEOUS ORIGIN

Transient transfection experiments indicated (i) that E6 protein of no n-cancer-associated cutaneous human papillomavirus type 1 (HPV-1) can inhibit p53-mediated transcriptional transactivation in both p53-defic ient human cells (H358) and normal rat cells (3Y1), but those of cance r-associated cutaneous HPV-5, -8, and -47 cannot do so in either H358 or 3Y1 cells, and (ii) that E6 proteins of HPV-16 and -18 can inhibit the p53 function in H358 cells but not in 3Y1 cells.