PROTEIN TRANSLOCATION - COMMON THEMES FROM BACTERIA TO MAN

Authors
JUNGNICKEL B RAPOPORT TA HARTMANN E
Citation
B. Jungnickel et al., PROTEIN TRANSLOCATION - COMMON THEMES FROM BACTERIA TO MAN, FEBS letters, 346(1), 1994, pp. 73-77
Citations number
43
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
346
Issue
1
Year of publication
1994
Pages
73 - 77
Database
ISI
SICI code
0014-5793(1994)346:1<73:PT-CTF>2.0.ZU;2-1
Abstract
Protein transport across the endoplasmic reticulum membrane in eukaryo tes and across the cytoplasmic membrane in bacteria have turned out to be highly related. The core component of the translocation apparatus is the Sec61/SecYp complex; at least two of its subunits are conserved in evolution. The Sec61/SecYp complex is involved in both co- and pos t-translational transport pathways. The two modes require probably dis tinct additional components.