SUCROSE IN A LIPID-RICH MEAL AMPLIFIES THE POSTPRANDIAL EXCURSION OF SERUM AND LIPOPROTEIN TRIGLYCERIDE AND CHOLESTEROL CONCENTRATIONS BY DECREASING TRIGLYCERIDE CLEARANCE

Nineteen young male normolipidemic volunteers sequentially consumed th ree test meals consisting of cream only, sucrose only, or cream with s ucrose. These oral fat-tolerance tests showed an amplification of the postprandial excursion of serum triglyceride and cholesterol concentra tions when sucrose was included in a lipid-rich meal compared with bot h the cream-only meal and the sucrose-only meal. The triglyceride conc entration increase occurred only in the late postprandial phase wherea s the cholesterol concentration was increased for the entire 8 h studi ed. The increased triglyceride and cholesterol concentrations in the t riglyceride-rich lipoprotein (TRL) fraction accounted for most of the increase. The clearance of an intravenous lipid emulsion was measured before and 2 and 4 h after a sucrose meal. The two postprandial cleara nce rates were 34% slower than the fasting value. These data indicate that sucrose-induced postprandial hypertriglyceridemia may be induced by an inhibition of the clearance of triglyceride. The slower rate of lipolysis may cause the accumulation of cholesterol in TRL.