EVALUATION OF HELICOBACTER-PYLORI ERADICATION WITH BISMUTH SUCRALFATE

Methods: In a pilot,study we have evaluated the clinical efficacy of b ismuth sucralfate to eradicate H. pylori. Ten consecutive patients wit h chronic dyspepsia and H. pylori associated gastritis were treated wi th bismuth sucralfate (220 mg bismuth per tablet, 4 tablets per day fo r 4 weeks). If a C-14 urea breath test immediately after the medicatio n was negative, a gastroscopy was performed one month later to obtain biopsies for culture and histological examination. Results: Four patie nts experienced side effects. In none of the ten patients could eradic ation of H. pylori be demonstrated one month after treatment with bism uth sucralfate. Conclusion: Bismuth sucralfate is not effective for th e treatment of H. pylori infection.