Background: The purpose of this study was to identify the etiology, pr
ecipitating factors, and main findings from clinical examination and n
oninvasive laboratory investigation in congestive heart failure (CHF)
in advanced age. Methods: This was an observational study conducted in
the geriatric ward of the A. Gemelli University Hospital, Rome. A tot
al of 154 consecutive subjects (age, 75 +/- 8 years; range, 60 to 98 y
ears) hospitalized with CHF were included in the study. All subjects w
ere assessed for history and underwent physical examination, ECG, cros
s-sectional echocardiography, chest radiography, and routine blood che
mistry; in selected patients, Tl-201 myocardial scintigraphy and Doppl
er echocardiography were used. Results: A multiple etiology of CHF was
found in 56% of the patients. Coronary artery disease was the most co
mmon single cause of CHF (71%), followed by hypertension (45%), valvul
ar heart disease (32%), and chronic cor pulmonale (13%). Factors preci
pitating CHF were evident in 62% of the patients, the most common bein
g atrial fibrillation (16%), use of nonsteroidal anti-inflammatory dru
gs (10%), lack of compliance with drugs (10%), renal failure (8%), fev
er (6.5%), and anemia (6%). Left ventricular systolic function, as ass
essed by echocardiography, was normal in 45% of patients. In each pati
ent the diagnosis of CHF was associated with an average of five unrela
ted diseases. New York Heart Association (NYHA) class III to IV severi
ty was the only condition that correlated with a higher prevalence of
impaired systolic function. Conclusions: In elderly patients, CHF repr
esents a complex entity whose diagnosis and treatment requires a compr
ehensive approach.