RELATIONS BETWEEN NEUROGENESIS AND ELECTR ICAL RESPONSES OF OLFACTORYRECEPTORS

Structural and functional changes in olfactory epithelium of laborator y mice were studied following the treatment of nasal cavity with zinc sulphate. Different concentrations of zinc sulphate caused olfactory e pithelium cells destruction, moreover the degree of this destruction d epended on concentration. Direct dependence between morphological rege neration and the EOG amplitude increase was observed after the treatme nt with 1 % zinc sulphate. The epithelium regeneration after the treat ment with higher concentration (3 and 5 %) was slower and the EOG ampl itude fell behind the increase of the olfactory epithelium thickness. The application of different olfactory stimuli allowed to establish th at the rate of reactions re-establishment differed with the odorous.