C. Santhosh et Pc. Mishra, ELECTRIC-FIELD MAPPING AND STRUCTURE-ACTIVITY-RELATIONSHIPS FOR SOME NEUROTRANSMITTERS - SEROTONIN CONGENERS, Journal of molecular structure. Theochem, 112(1), 1994, pp. 77-81
Electric field maps of neutral and cationic forms of 5-hydroxytryptami
ne (serotonin), 5-chlorotryptamine, 6-hydroxytryptamine and 4-hydroxyt
ryptamine have been studied. The binding of these species through the
substituent at position 5 and the amino group, with the receptor, are
shown to be of crucial significance. A relationship between the observ
ed potencies of the different compounds and electric fields near the s
ubstituent at position 5, has been shown to exist.