ELECTRIC-FIELD MAPPING AND STRUCTURE-ACTIVITY-RELATIONSHIPS FOR SOME NEUROTRANSMITTERS - SEROTONIN CONGENERS

Electric field maps of neutral and cationic forms of 5-hydroxytryptami ne (serotonin), 5-chlorotryptamine, 6-hydroxytryptamine and 4-hydroxyt ryptamine have been studied. The binding of these species through the substituent at position 5 and the amino group, with the receptor, are shown to be of crucial significance. A relationship between the observ ed potencies of the different compounds and electric fields near the s ubstituent at position 5, has been shown to exist.