ALKALOIDS FROM THE ANTARCTIC SPONGE KIRKPATRICKIA-VARIALOSA .2. VARIOLIN-A AND N(3')-METHYL TETRAHYDROVARIOLIN-B

Authors
TRIMURTULU G FAULKNER DJ PERRY NB ETTOUATI L LITAUDON M BLUNT JW MUNRO MHG JAMESON GB
Citation
G. Trimurtulu et al., ALKALOIDS FROM THE ANTARCTIC SPONGE KIRKPATRICKIA-VARIALOSA .2. VARIOLIN-A AND N(3')-METHYL TETRAHYDROVARIOLIN-B, Tetrahedron, 50(13), 1994, pp. 3993-4000
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
13
Year of publication
1994
Pages
3993 - 4000
Database
ISI
SICI code
0040-4020(1994)50:13<3993:AFTASK>2.0.ZU;2-D
Abstract
Two pyridopyrrolopyrimidine alkaloids, variolin A (2) and N(3')-methyl tetrahydrovariolin B (3), have been isolated from the Antarctic spong e Kirkpatrickia varialosa, and their structures determined by X-ray cr ystallography and interpretation of spectral data respectively. N(3')- Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed ant ifungal activity, while variolin A (2) is weakly cytotoxic.