SYNTHESIS AND COMPLEMENTARY COMPLEX-FORMATION PROPERTIES OF OLIGONUCLEOTIDES COVALENTLY-LINKED TO NEW STABILIZING AGENTS

Authors
BALBI A SOTTOFATTORI E GRANDI T MAZZEI M ABRAMOVA TV LOKHOV SG LEBEDEV AV
Citation
A. Balbi et al., SYNTHESIS AND COMPLEMENTARY COMPLEX-FORMATION PROPERTIES OF OLIGONUCLEOTIDES COVALENTLY-LINKED TO NEW STABILIZING AGENTS, Tetrahedron, 50(13), 1994, pp. 4009-4018
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
13
Year of publication
1994
Pages
4009 - 4018
Database
ISI
SICI code
0040-4020(1994)50:13<4009:SACCPO>2.0.ZU;2-2
Abstract
Oligodeoxyribonucleotides of different lengths have been prepared and linked to new stabilizing agents related to the coumarin family. These ODNSAs (OligoDeoxyriboNucleotides with Stabilizing Agents) were teste d against acridine connected oligomers of the same sequence. Melting t emperature experiments demonstrated that all ODNSAs formed complexes o f increased stability with complementary sequences of deoxyribo-20-mer . The order of stability of duplexes showed that the coumarins stabili ze the complexes more than the acridine and the chromone derivatives.