We outline a continuum solvation model for aqueous solution similar to
the recent SMx models of Cramer and Truhlar.(1-3) As in those models,
the solvation energy is given as a sum of polarization and cavity-dis
persion contributions. The numerical integration required for calculat
ion of the polarization energy in the SMx models has been replaced by
a scaled two-center Coulomb integral. The cavity-dispersion energy is
based on molecular volume and includes a term involving the molecular
dipole moment. The present method is more accurate than the SMx models
and is considerably less time-consuming.