An extreme lateral transcondylar or extreme lateral transfacetal surgi
cal approach was used to treat 22 patients with complex lesions over a
22-month period. The lesions included basilar invagination with verte
bral artery pathology, giant aneurysm or arteriovenous fistula of the
vertebral artery, meningioma, chordoma, chondrosarcoma, and paragangli
oma. The approach was used alone or in combination with a presigmoid p
etrosal or subtemporal-infratemporal approach. Refinements of the oper
ative technique, treatment strategies for complex lesions, and the avo
idance of complications are discussed. Complications included cerebros
pinal fluid leakage, meningitis, pseudomeningocele, hemiparesis or qua
driparesis, lower cranial nerve deficits, and vertebral artery injury
requiring repair. With treatment, major neurological deficits resolved
completely in three patients and partially in two. There was no opera
tive mortality, but four patients died during the follow-up period. Fo
r the 18 surviving patients, the mean preoperative and postoperative K
arnofsky scores were 81 and 93, respectively. For the four who died, t
he mean preoperative Karnofsky score was 73 and the mean postoperative
score was 63.