FLECAINIDE-INDUCED JT PROLONGATION, T-WAVE INVERSION AND VENTRICULAR-TACHYCARDIA DURING TREATMENT FOR SYMPTOMATIC ATRIAL-FIBRILLATION

Two hours after taking 100 mg of flecainide, a patient developed gastr ointestinal complaints, dizziness and shortness of breath. The ECG dem onstrated novel prolonged JT interval with negative T wave in the prec ordial leads. During admission, several attacks of non-sustained ventr icular tachycardia occurred. The plasma drug concentration was 814 mg/ l. Although the tachycardia was non-sustained, cardiovascular collapse developed. Serum electrolytes were normal and myocardial infarction w as excluded. The patient is now free of symptoms without medications.