The Drosophila Son of sevenless (Sos) gene functions in the signaling
pathway initiated by the Sevenless receptor tyrosine kinase. It encode
s the Drosophila homologue of CDC25, an activator of Ras in the yeast
Saccharomyces cerevisiae. Two widely expressed mammalian homologues of
Sos (mSos) have now been identified and characterized They encode for
150-kD proteins that ave Ras-specific guanine nucleotide exchange fac
tors. Generic and biochemical studies indicate that Sos proteins bind
directly to the SH2- and SH3-domain-containing adaptor protein GRB2/Dr
k. This interaction defines a pathway by which receptor tyrosine kinas
es can communicate with Ras.