MICELLE-STABILIZED ROOM-TEMPERATURE PHOSPHORIMETRIC PROCEDURE FOR THEDETERMINATION OF NAPROXEN AND PROPRANOLOL IN PHARMACEUTICAL PREPARATIONS

A direct and simple procedure for the determination of naproxen and pr opranolol in pharmaceutical preparations was developed. The procedure was based on the measurement of the room-temperature phosphorescence o f sodium dodecyl sulfate micellar solutions of the drugs. The appropri ate experimental conditions to obtain a reproducible and maximum phosp horescence signal, when sulfite is used to eliminate the oxygen from t he micellar solutions, were studied. The results of the analysis of se veral pharmaceutical preparations were satisfactory. The presence of h ydralazine in pharmaceuticals containing propranolol gave low values o wing to quenching of the phosphorescence signal.